Nucleofill strong 2.5% 1.5ml Syringe

Nucleofill 25 (Strong) is a bio stimulant gel based on natural polynucleotides and high viscosity for skin rejuvenation and protection. As an anti-ageing treatment. Nucleofill is designed to improve skin elasticity and tightness as well as aid in the prevention of wrinkles. Nucleofill 25 is the new line of natural polynucleotide-based bio stimulating gels, with a high viscosity, for protecting and rejuvenating the skin. It’s recommended to have 2 treatments with 2-4 weeks in between each session, in severe cases you can have up to 4 treatments with 2-4 weeks intervals.

The product contains high molecular weight polynucleotide chains whose biochemical peculiarities make it highly viscoelastic and capable of binding and orient in space a considerable amount of water molecules, which are primarily retained in the hydrophilic groups level of phosphorylated sugars of the individual nucleotides.

The strong moisturising ability is mainly due to the water retention capabilities of the hydrophilic groups of the phosphorylated sugars of the single nucleotides. An “electrostatic sponge” able to guarantee cellular well-being by conferring deep hydration to tissues.

Free radical scavenger effect – The polymeric macromolecules are able to also play an immediate “scavenger” action against free radicals. This effect of this polynucleotide gel is possible thanks to the chemical structure capable of blocking free radicals in the nitrogenous ring. Moreover, the progressive degradation of polynucleotide molecules by enzymes present in the extracellular environment, free metabolites which, in turn, accentuate the protection activity against free radicals.

The biostimulating effect is given both by the presence of nucleoside structures capable of activating cell membrane receptors, and by metabolites that are produced by the enzymatic attack during the degradation process. A slow and continuous effect.

By promoting the metabolic activity of the fibroblastic cells, polynucleotides collaborate to reintegrate into the dermis various fundamental autologous components (glucoseaminoglycans, proteins, glycoproteins, fibrils, etc.) tending to maintain their physiological functionality. Their repeated administration over time, determines:
– a protracted isosmotic hydration of the dermal matrix
– an anti-radical action
Both of these effects combine to recreate in the dermal matrix the most favourable physiological conditions for the regeneration and metabolic activity of fibroblasts, with long-lasting biorevitalising effects.

Polynucleotides activate two types of membrane receptors in fibroblasts, or rather Receptor CD39 and Receptor CD40. The activation of these receptors lead to two effects: stimulation of type I collagen production, saturation of fibroblasts in myofibroblasts

Contains:
25mg/ml of polynucleotides

The synergy of 4 types of stimulation:
– Skin regeneration
– Cleansing effect on the cells by increasing circulation and removing  free radicals
– Deep moisturising effect
– Firming and contouring

Indications:
– Loose skin with poor circulation
– Dehydrated skin
– Skin submitted to oxidative stress
– Stretch marks
– Scars
– For those who want firming and contouring, more definition
– Bio-stimulation and increase in collagen type 1.

At the basket, you will be asked per line whether each prescription-eligible item is being ordered on prescription for a named patient or as clinic stock under your responsibility.

Named-patient prescription supply. Lines marked for a named patient are dispensed against your prescription. The order is held for Superintendent Pharmacist review before despatch. Prescription supply is zero-rated for VAT.

Clinic stock supply. Lines marked as clinic stock are supplied under your professional responsibility for use in your practice. Standard VAT applies at checkout.

Orders containing prescription-only medicines (POM) are held until the Superintendent Pharmacist has cleared the prescription. Same-day dispatch applies once cleared.

For questions about prescription supply, contact admin@longevapharma.com or reply to your order confirmation email.

Dispatch: Orders approved before 3pm Monday to Friday ship the same day for next-working-day delivery via tracked courier. Cold-chain products travel in temperature-controlled packaging.

Returns: Sealed, in-date, unopened items may be returned within 14 days of delivery for a full refund. Cold-chain items cannot be returned once dispatched. Contact our trade team to start a return.

Documentation: Every dispatch includes batch and expiry information suitable for your clinic's compliance records.