Nucleofill strong 2.5% 1.5ml Syringe

Nucleofill 25 (Strong) is a bio stimulant gel based on natural polynucleotides and high viscosity for skin rejuvenation and protection. As an anti-ageing treatment. Nucleofill is designed to improve skin elasticity and tightness as well as aid in the prevention of wrinkles. Nucleofill 25 is the new line of natural polynucleotide-based bio stimulating gels, with a high viscosity, for protecting and rejuvenating the skin. It’s recommended to have 2 treatments with 2-4 weeks in between each session, in severe cases you can have up to 4 treatments with 2-4 weeks intervals.

The product contains high molecular weight polynucleotide chains whose biochemical peculiarities make it highly viscoelastic and capable of binding and orient in space a considerable amount of water molecules, which are primarily retained in the hydrophilic groups level of phosphorylated sugars of the individual nucleotides.

The strong moisturising ability is mainly due to the water retention capabilities of the hydrophilic groups of the phosphorylated sugars of the single nucleotides. An “electrostatic sponge” able to guarantee cellular well-being by conferring deep hydration to tissues.

Free radical scavenger effect – The polymeric macromolecules are able to also play an immediate “scavenger” action against free radicals. This effect of this polynucleotide gel is possible thanks to the chemical structure capable of blocking free radicals in the nitrogenous ring. Moreover, the progressive degradation of polynucleotide molecules by enzymes present in the extracellular environment, free metabolites which, in turn, accentuate the protection activity against free radicals.

The biostimulating effect is given both by the presence of nucleoside structures capable of activating cell membrane receptors, and by metabolites that are produced by the enzymatic attack during the degradation process. A slow and continuous effect.

By promoting the metabolic activity of the fibroblastic cells, polynucleotides collaborate to reintegrate into the dermis various fundamental autologous components (glucoseaminoglycans, proteins, glycoproteins, fibrils, etc.) tending to maintain their physiological functionality. Their repeated administration over time, determines:
– a protracted isosmotic hydration of the dermal matrix
– an anti-radical action
Both of these effects combine to recreate in the dermal matrix the most favourable physiological conditions for the regeneration and metabolic activity of fibroblasts, with long-lasting biorevitalising effects.

Polynucleotides activate two types of membrane receptors in fibroblasts, or rather Receptor CD39 and Receptor CD40. The activation of these receptors lead to two effects: stimulation of type I collagen production, saturation of fibroblasts in myofibroblasts

Contains:
25mg/ml of polynucleotides

The synergy of 4 types of stimulation:
– Skin regeneration
– Cleansing effect on the cells by increasing circulation and removing  free radicals
– Deep moisturising effect
– Firming and contouring

Indications:
– Loose skin with poor circulation
– Dehydrated skin
– Skin submitted to oxidative stress
– Stretch marks
– Scars
– For those who want firming and contouring, more definition
– Bio-stimulation and increase in collagen type 1.

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Where a product genuinely supports both routes, you choose whether you are ordering that item on prescription for a named patient or as clinic stock under your professional responsibility when you select it on the product page.

Named-patient prescription supply. Items chosen for a named patient are dispensed against your prescription. The order is held for Superintendent Pharmacist review before despatch. Prescription supply is zero-rated for VAT.

Clinic stock supply. Where eligible, items chosen as clinic stock are supplied under your professional responsibility for use in your practice. Standard VAT applies at checkout. This route is never offered for prescription-only medicines.

Orders containing prescription-only medicines are held until the Superintendent Pharmacist has cleared the prescription. Same-day dispatch applies once cleared.

For questions about prescription supply, contact admin@longevapharma.com or reply to your order confirmation email.

Delivery: Dispatch and delivery depend on stock, cleared payment, customer eligibility and any required prescription or pharmacy checks. Delivery estimates are not guarantees. See our Shipping and Delivery Policy.

Returns: Because storage history, product integrity, traceability and chain of custody cannot be verified after regulated healthcare goods leave our control, medicines, cold-chain goods, sterile products, injectables and other regulated products cannot normally be returned after dispatch. This does not affect remedies for goods supplied incorrectly, damaged or defective. See our Returns and Refunds Policy.

Cold chain: Temperature-sensitive products must be received promptly and transferred to the required storage conditions. If damage or a suspected temperature excursion is identified, quarantine the goods, retain all packaging and contact Longeva Pharma before use.