VITARAN Polynucleotides: The Complete Guide to Under-Eye & Skin Rejuvenation

Fine lines around the eyes. Crepey under-eye skin. Dark circles. Puffiness. Changes in texture, hydration and firmness.

These concerns don't always need to be approached by adding volume.

VITARAN is a CE-marked injectable polynucleotide treatment designed to support skin rejuvenation, regeneration and repair. Its formulation contains 20 mg/ml polynucleotide (PN 2%) derived from trout DNA.

At Longeva Aesthetics, VITARAN can be considered for patients interested in improving skin quality rather than simply changing facial contours.

The range includes VITARAN I, particularly relevant to the delicate skin around the eyes, and VITARAN II, designed for larger treatment areas.

But what is the difference? What can VITARAN realistically improve? And what does the clinical evidence actually tell us? This guide explains it.

What Are Polynucleotides?

Polynucleotides have become an important part of regenerative aesthetics because the treatment objective is fundamentally different from simply adding volume.

VITARAN's official product information describes the treatment as bio-stimulating, with anti-inflammatory properties and an intended role in skin rejuvenation, regeneration and repair at a cellular level.

This makes polynucleotide treatment particularly interesting for concerns involving the condition and appearance of the skin itself.

What Is VITARAN?

VITARAN is a CE-marked polynucleotide injectable. Its stated composition is 20 mg/ml polynucleotide — PN 2%, derived from trout DNA.

According to the official product information, treatment areas can include the periorbital/under-eye area, full face, neck, chest, décolletage, hands, stomach and arms.

There are two presentations particularly important to understand: VITARAN I and VITARAN II.

VITARAN for the Eyes: What Is VITARAN I?

Search online and you'll frequently see people looking for “VITARAN Eyes” or “VITARAN under eyes.” The official product document refers to the eye-focused presentation as VITARAN I.

VITARAN I is supplied as 2 × 1 ml syringes and is indicated in the manufacturer's material for improvement of the periorbital area.

What Under-Eye Concerns Can VITARAN I Target?

• Periocular fine lines and wrinkles
• Crepey under-eye skin
• Mild-to-moderate hollows
• Dark circles
• Eye bags
• Puffiness

This makes VITARAN particularly interesting when the concern is related to under-eye skin quality.

Why Treating the Under-Eye Area Requires Careful Assessment

“Dark circles” and “eye bags” sound like single concerns, but the appearance of the under-eye area can have different contributing factors. Someone with predominantly crepey skin may require a very different treatment strategy from somebody whose concern relates primarily to volume or anatomy.

That's why consultation and assessment matter. At Longeva Aesthetics, the objective isn't to fit every under-eye concern to the same treatment. It's to understand the concern first and determine whether VITARAN is appropriate.

Can VITARAN Help Crepey Under-Eye Skin?

Crepey under-eye skin is specifically listed among VITARAN I's indications.

The official VITARAN material also describes benefits including improved hydration, tone and texture, increased collagen and elastin production, improved firmness and elasticity and reduced appearance of fine lines and wrinkles.

This helps explain why polynucleotides are considered when the treatment objective is skin quality rather than simply volume replacement.

Can VITARAN Help Dark Circles?

Dark circles are also specifically included in VITARAN I's official indications. VITARAN's benefits material additionally states that the treatment increases HA synthesis to brighten the under-eye area.

However, this should not be interpreted as meaning that every case of dark circles can be corrected with VITARAN. Different factors can contribute to their appearance, which is why individual assessment remains important.

VITARAN II: Polynucleotides for Larger Treatment Areas

VITARAN II is supplied as 2 × 2 ml syringes and is positioned in the official documentation for larger treatment areas, including the full face, neck, hands, chest, décolletage and areas of the body including the stomach and arms.

It therefore extends the VITARAN approach to skin-quality concerns beyond the periorbital area.

VITARAN I vs VITARAN II: What's the Difference?

VITARAN II isn't simply a stronger version of VITARAN I.

The manufacturer's documentation states that VITARAN I and VITARAN II have exactly the same formulation and PN concentration of 2%. The stated difference is the syringe size, allowing more precise application to different treatment areas.

Treatment selection therefore depends on the treatment area and individual treatment plan, rather than choosing one because it contains a higher PN concentration.

What Are the Benefits of VITARAN Polynucleotides?

Collagen and Elastin

VITARAN states that treatment increases the production of collagen and elastin.

Hydration, Tone and Texture

The manufacturer lists improvement in skin hydration, tone and texture.

Firmness and Elasticity

Improved skin firmness and elasticity are also among the stated benefits.

Fine Lines and Wrinkles

The product information states that VITARAN can reduce the appearance of fine lines and wrinkles.

Regeneration and Skin Barrier

VITARAN additionally describes improved cell regeneration, enhanced skin healing and regeneration, and repair of the skin's natural barrier. The material also describes antioxidant and anti-inflammatory properties.

These are manufacturer-stated benefits and should not be interpreted as a guarantee that every patient will experience every outcome.

What Does the Clinical Research Show?

This is where it's important to separate marketing claims from clinical evidence.

The official VITARAN document references the study “Effects of Polynucleotide in the Correction of Crow's Feet Using an Antera Three-Dimensional Camera.”

The study involved 30 healthy volunteers aged 19–60 years with crow's-feet grading scores of 2–4. Participants received four treatments at two-week intervals.

The VITARAN document reports that wrinkles improved without significant adverse reactions and states that the volunteers were satisfied with the results and wanted to repeat treatment. It also reports observed improvement relating to pores, texture and skin tone, in addition to crow's feet.

What About the 84.4%, 88.4% and 93.2% Figures?

The VITARAN clinical material displays reported improvement rates of 84.4% at week 8, 88.4% at week 10 and 93.2% at week 18.

These figures relate to the study presented in VITARAN's supplied clinical material. They should not be interpreted as meaning an individual patient has a 93.2% chance of improvement, nor as a guaranteed level of cosmetic improvement.

Clinical Study Schedule vs VITARAN's Current Treatment Protocol

The clinical study described above used four treatments at two-week intervals. VITARAN's separate treatment-protocol section recommends 2–3 treatments spaced 3–4 weeks apart.

These are not the same thing: one describes the research study design, while the other is the treatment protocol supplied in the VITARAN marketing document.

How Many VITARAN Treatments Are Recommended?

VITARAN's official treatment protocol recommends 2–3 treatments spaced 3–4 weeks apart. It also states that optimum results show 2–4 weeks post-treatment.

An individual treatment plan should nevertheless be based on consultation, treatment area, skin condition and clinical assessment.

How Is VITARAN Administered?

The manufacturer's professional protocol describes administration using either a cannula or superficial microdroplet technique.

Cannula Technique

The protocol describes a 25G cannula, with injection into deeper layers of the skin.

Microdroplet Technique

The supplied protocol describes a 34G 4 mm needle, with superficial injection for concerns including fine lines, crepey skin and pigmentation. It specifies 0.02–0.05 cc per point, approximately 1.5–2 cm apart. For the under-eye area, the document specifies 0.5 ml per eye.

These details describe a professional treatment protocol and are not instructions for self-administration.

VITARAN vs Dermal Filler: What's the Difference?

Although both treatments are injectable, their purposes are different. Dermal filler is typically used where the treatment objective involves volume or contour.

VITARAN is described instead as a bio-stimulating polynucleotide treatment supporting skin rejuvenation, regeneration and repair.

This distinction is especially important around the eyes. A patient concerned about crepey skin and fine lines may need a very different treatment approach from someone whose concern is predominantly structural volume loss.

VITARAN Under Eyes vs Tear Trough Filler

This is not simply a question of which treatment is “better”. They address different treatment objectives.

VITARAN I is specifically positioned for the periorbital area, with manufacturer-listed concerns including fine lines, crepey under-eye skin, mild-to-moderate hollows, dark circles, eye bags and puffiness. Tear trough filler is primarily a volume-based approach.

An appropriate consultation should therefore establish what is causing the appearance of the under-eye area before selecting a treatment.

Does VITARAN Have Downtime?

The official VITARAN information states that bruising or swelling may be apparent for up to one week following injection.

Its aftercare information also advises avoiding makeup for 12 hours and avoiding sun/UV exposure, cold and heat exposure for up to two weeks. Individual aftercare advice should be provided following treatment.

Who Should Not Have VITARAN?

Aesthetic treatment should begin with suitability and safety, not the injection.

VITARAN's supplied contraindications include patients with a history of unabsorbable filler or recent filler treatment and patients taking certain medicines, including NSAIDs, platelet aggregation inhibitors, anticoagulants or immunosuppressants.

The manufacturer's list also includes allergic disease, fish allergies, autoimmune disease, sarcoidosis granulomatous pathology, Osler's endocarditis, keloid scarring, hypersensitivity to sodium polynucleotide, pregnancy or breastfeeding, and patients under 18.

This is why medical history, medication and previous aesthetic treatment should form part of the consultation process.

Is VITARAN Right for You?

Around the Eyes

Fine lines, crepey skin, dark circles, puffiness or other changes in periorbital skin quality.

Face

Changes in overall skin texture, hydration, firmness or appearance.

Neck and Décolletage

Skin-quality concerns extending beyond the face.

Hands

Another area specifically included within VITARAN II's treatment indications.

The important word, however, is suitability. A treatment being available for a particular concern doesn't automatically mean it's the right treatment for every person with that concern.

Why Choose Longeva Aesthetics for Your VITARAN Consultation?

Good aesthetic treatment starts before a product is selected.

At Longeva Aesthetics, your consultation should establish what you're actually trying to improve, assess the treatment area and determine whether a polynucleotide treatment is appropriate for you.

For the under-eye area in particular, this distinction matters. Dark circles, hollows, puffiness, fine lines and crepey skin can look superficially similar while requiring very different treatment considerations.

The objective isn't simply to “have VITARAN.” It's to determine whether VITARAN is the appropriate treatment for you.

VITARAN Frequently Asked Questions

Is VITARAN the same as a skin booster?

VITARAN is specifically described in its official material as a polynucleotide injectable containing 20 mg/ml PN (2%). It should therefore be understood according to its polynucleotide composition rather than treating all injectable skin-quality treatments as interchangeable.

What is VITARAN Eyes?

“VITARAN Eyes” is useful shorthand when discussing VITARAN treatment around the eyes. The official product material calls the eye-focused presentation VITARAN I, which is supplied in 2 × 1 ml syringes and indicated for the periorbital area.

What's the difference between VITARAN I and VITARAN II?

Both contain the same 2% PN concentration and formulation. The official material states that the difference is syringe size, allowing application to different treatment areas.

Can VITARAN help dark circles?

Dark circles are specifically listed among VITARAN I's indications. However, under-eye darkness can have different contributing factors, so suitability requires individual assessment.

Can VITARAN help eye bags?

Eye bags and puffiness are also included in the manufacturer's VITARAN I indications. Whether VITARAN is appropriate depends on what's contributing to the appearance.

How many VITARAN treatments do I need?

The official treatment protocol recommends 2–3 treatments spaced 3–4 weeks apart. Your individual treatment plan may depend on assessment and treatment area.

When should I see VITARAN results?

The manufacturer's protocol states that optimum results show 2–4 weeks post-treatment. Results and response vary between individuals.

Is there downtime?

The supplied product information states that bruising or swelling may be apparent for up to one week following injection.

Book a VITARAN Polynucleotide Consultation at Longeva Aesthetics

If you're considering VITARAN for the under-eyes, face, neck, décolletage, hands or another appropriate treatment area, the first step is a consultation.

We'll assess your concerns, discuss what you're hoping to achieve and determine whether VITARAN I, VITARAN II or another treatment approach is appropriate.

Book your VITARAN consultation with Longeva Aesthetics.