{"title":"Nucleofill","description":"\u003cp\u003eDiscover Nucleofill, an innovative polynucleotide-based treatment range designed to rejuvenate skin at a cellular level through bio-remodelling technology. This advanced collection is ideal for qualified practitioners offering cutting-edge skin quality treatments, hydration therapy, and anti-ageing solutions with natural, regenerative results.\u003c\/p\u003e","products":[{"product_id":"nucleofill-hair-1-x-2ml","title":"Nucleofill Hair 2% 2ml Syringe","description":"\u003cp\u003eThis prodcut was previously named Nucleofill Medium Plus\u003c\/p\u003e\n\u003cp\u003eNucleofill Hair showed a significant effectiveness in the treatment of androgenetic alopecia and in all cases of hair weakening, improving the trophism of the hair follicle thanks to its deep and continuous biorestructuring effect.\u003cbr\u003eThe use of polynucleotides has a targeted action at receptor level, by reducing the affinity for androgens (acting as a false sublayer) and also improves the cellular energetic profile with consequent enhancement of enzymatic activities, including aromatase.\u003c\/p\u003e\n\u003cp\u003eTheir action is also appreciated at the microcirculatory level, by increasing the formation of new micro-vessels, improving oxygenation and the districtual nutrition supply.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eCharacteristics:\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePolynucleotide gel 20 mg in 2 ml\u003c\/li\u003e\n\u003cli\u003eMolecular weight of about 1.500KD MW\u003c\/li\u003e\n\u003cli\u003epH between 6.8 e 7.2\u003c\/li\u003e\n\u003cli\u003eViscosity 35- 43 Pa*s\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits:\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eHair loss reduction\u003c\/li\u003e\n\u003cli\u003eImprovement of hair quality\u003c\/li\u003e\n\u003cli\u003eImprovement of hair thickness\u003c\/li\u003e\n\u003cli\u003eThickening of hairbrow\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eA box contains 1 syringe of 2.0ml\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eKey Ingredients:\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePolydeoxyribonucleotides\u003c\/strong\u003e: molecules that make up our DNA, our genetic code, which is why they are very precious molecules for the body and cells. Their main feature, in addition to transmitting genetic information, is that of being able to activate many cell membrane receptors, and trigger biological processes that are fundamental for the life of the cells themselves\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Nucleofill","offers":[{"title":"Default Title","offer_id":57717429895516,"sku":"LPBST236","price":75.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1018\/4923\/5804\/files\/NUCLEOFILL_HAIR_3.jpg?v=1779540900"},{"product_id":"nucleofill-age-1-x-2ml","title":"Nucleofill Age 2.5% 2ml Syringe","description":"\u003cmeta charset=\"UTF-8\"\u003e\n\u003cp\u003eNucleofill Age (Medium Plus 2.5%) offers intense hydration and stimulates collagen for a youthful, radiant complexion. \u003c\/p\u003e\n\u003ch4\u003eKey Features\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eMedium-viscosity polynucleotide gel delivers long-lasting moisture and plumps the skin.\u003c\/li\u003e\n\u003cli\u003e2.5% polynucleotide concentration stimulates collagen for improved skin elasticity.\u003c\/li\u003e\n\u003cli\u003eHelps combat free radicals that contribute to skin aging.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eTreatment Areas\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eFace (cheeks, forehead, around the mouth and eyes).\u003c\/li\u003e\n\u003cli\u003eNeck and décolletage\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eComposition\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e 2.5% polynucleotide gel\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePacket Contains\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e1 x 2ml Sterile Vial \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eQuality Assurance\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eCE marked for safety.\u003cbr\u003e \u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Nucleofill","offers":[{"title":"Default Title","offer_id":57717430124892,"sku":"LPBST237","price":80.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1018\/4923\/5804\/files\/NUCLEOFILL_AGE_3.jpg?v=1779540909"},{"product_id":"nucleofill-eyes-1-x-2ml","title":"Nucleofill Eyes (soft) 0.75% 2ml Syringe","description":"\u003cmeta charset=\"UTF-8\"\u003e\n\u003csection id=\"intro\" class=\"bg-black pv-20\"\u003e\n\u003cdiv class=\"container mb-60\"\u003e\n\u003cdiv class=\"flex center row\"\u003e\n\u003cdiv class=\"col-xs-12 col-sm-offset-1 col-sm-7\"\u003e\n\u003cp\u003eThe new bio-restructuring gel of the Nucleofill range based on highly purified low molecular weight polynucleotides of natural origin, specifically created to improve the periocular area.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e\n\u003csection id=\"indications\" class=\"bg-white\"\u003e\n\u003cdiv class=\"relative pv-120\"\u003e\n\u003cdiv class=\"container\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"col-md-5 col-lg-6\"\u003e\n\u003cp\u003eThe periocular area is an extremely delicate area. Constantly subjected to environmental pollution and constantly subject to movement when using facial expressions, the periocular area tends to age more rapidly than the rest of the face.\u003c\/p\u003e\n\u003cp\u003eNucleofill Eyes with highly purified polynucleotide matrix capable of activating the skin’s bio-regeneration processes both deep down (fat and bone tissue) and in the dermis (fibroblast stimulation).\u003c\/p\u003e\n\u003cp\u003eNucleofill Eyes determines three types of effects on the skin membrane (epidermis, dermis and subcutaneous tissue):\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEffect on the dermal-epidermal layer\u003c\/li\u003e\n\u003cli\u003eEffect on the vascular level\u003c\/li\u003e\n\u003cli\u003eEffect on the deep tissue level\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eNucleofill Eyes – the unique characteristics of an innovative product:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eNucleofill Eyes is a gel composed of low molecular weight polynucleotide chain fragments\u003c\/li\u003e\n\u003cli\u003eThe high density but low molecular weight structure allows a fast penetration into the tissues and an efficient stimulation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eIndications\u003c\/h2\u003e\n\u003cp\u003eNucleofill Eyes is specifically designed to improve:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBags \/ Bags under the eyes\u003c\/li\u003e\n\u003cli\u003ePeriocular wrinkles\u003c\/li\u003e\n\u003cli\u003eRegenerate the skin in the periocular area\u003c\/li\u003e\n\u003cli\u003eBio-restructuring of deep tissues\u003c\/li\u003e\n\u003cli\u003eImprovement of superficial wrinkles without the use of fillers\u003c\/li\u003e\n\u003cli\u003ePre- and post-surgical treatment (such as blepharoplasty, surgical eye lift, laser)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/section\u003e","brand":"Nucleofill","offers":[{"title":"Default Title","offer_id":57717432287580,"sku":"LPBST238","price":75.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1018\/4923\/5804\/files\/NUCLEOFILL_EYES_3.jpg?v=1779540918"},{"product_id":"nucleofill-25-1-x-1-5ml","title":"Nucleofill strong 2.5% 1.5ml Syringe","description":"\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eNucleofill 25 (Strong) is a  bio stimulant gel based on natural polynucleotides and high viscosity for skin rejuvenation and protection. As an anti-ageing treatment. Nucleofill is designed to improve skin elasticity and tightness as well as aid in the prevention of wrinkles. Nucleofill 25 is the new line of natural polynucleotide-based bio stimulating gels, with a high viscosity, for protecting and rejuvenating the skin. It’s recommended to have 2 treatments with 2-4 weeks in between each session, in severe cases you can have up to 4 treatments with 2-4 weeks intervals.\u003c\/p\u003e\n\u003cp class=\"\"\u003eThe product contains high molecular weight polynucleotide chains whose biochemical peculiarities make it highly viscoelastic and capable of binding and orient in space a considerable amount of water molecules, which are primarily retained in the hydrophilic groups level of phosphorylated sugars of the individual nucleotides.\u003c\/p\u003e\n\u003cp class=\"\"\u003eThe strong moisturising ability is mainly due to the water retention capabilities of the hydrophilic groups of the phosphorylated sugars of the single nucleotides. An “electrostatic sponge” able to guarantee cellular well-being by conferring deep hydration to tissues.\u003c\/p\u003e\n\u003cp\u003eFree radical scavenger effect – The polymeric macromolecules are able to also play an immediate “scavenger” action against free radicals. This effect of this polynucleotide gel is possible thanks to the chemical structure capable of blocking free radicals in the nitrogenous ring. Moreover, the progressive degradation of polynucleotide molecules by enzymes present in the extracellular environment, free metabolites which, in turn, accentuate the protection activity against free radicals.\u003c\/p\u003e\n\u003cp class=\"\"\u003eThe biostimulating effect is given both by the presence of nucleoside structures capable of activating cell membrane receptors, and by metabolites that are produced by the enzymatic attack during the degradation process. A slow and continuous effect.\u003c\/p\u003e\n\u003cp class=\"\"\u003eBy promoting the metabolic activity of the fibroblastic cells, polynucleotides collaborate to reintegrate into the dermis various fundamental autologous components (glucoseaminoglycans, proteins, glycoproteins, fibrils, etc.) tending to maintain their physiological functionality. Their repeated administration over time, determines:\u003cbr\u003e– a protracted isosmotic hydration of the dermal matrix\u003cbr\u003e– an anti-radical action\u003cbr\u003eBoth of these effects combine to recreate in the dermal matrix the most favourable physiological conditions for the regeneration and metabolic activity of fibroblasts, with long-lasting biorevitalising effects.\u003c\/p\u003e\n\u003cp class=\"\"\u003ePolynucleotides activate two types of membrane receptors in fibroblasts, or rather Receptor CD39 and Receptor CD40. The activation of these receptors lead to two effects: stimulation of type I collagen production, saturation of fibroblasts in myofibroblasts\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContains:\u003c\/strong\u003e\u003cbr\u003e25mg\/ml of polynucleotides\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThe synergy of 4 types of stimulation:\u003c\/strong\u003e\u003cbr\u003e– Skin regeneration\u003cbr\u003e– Cleansing effect on the cells by increasing circulation and removing  free radicals\u003cbr\u003e– Deep moisturising effect\u003cbr\u003e– Firming and contouring\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications:\u003cbr\u003e\u003c\/strong\u003e– Loose skin with poor circulation\u003cbr\u003e– Dehydrated skin\u003cbr\u003e– Skin submitted to oxidative stress\u003cbr\u003e– Stretch marks\u003cbr\u003e– Scars\u003cbr\u003e– For those who want firming and contouring, more definition\u003cbr\u003e– Bio-stimulation and increase in collagen type 1.\u003c\/p\u003e","brand":"Nucleofill","offers":[{"title":"Default Title","offer_id":57717432484188,"sku":"LPBST239","price":65.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1018\/4923\/5804\/files\/NUCLEOFILL_25_3.jpg?v=1779540927"},{"product_id":"nucleofill-20-1-x-1-5ml","title":"Nucleofill 20 (medium) 2% 1.5ml Syringe SHORT DATED 03\/2026","description":"\u003cmeta charset=\"UTF-8\"\u003e\n\u003cp\u003eNucleofill 20 (Medium) is a new line of sterile sodium DNA-based gel with hydrating properties, specific for young skin. As an anti-ageing treatment, Nucleofill is designed to improve skin elasticity and tightness as well as aid in the prevention of wrinkles.\u003c\/p\u003e\n\u003cp\u003esupports skin regeneration as well as the outwardly visible improvement of the skin’s appearance.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReduces light to moderate wrinkles such as perioral wrinkles or creases on the cheeks.\u003c\/li\u003e\n\u003cli\u003eReduces medium-sized scars and stretch marks.\u003c\/li\u003e\n\u003cli\u003eEffectively tightens sagging or drooping skin in areas such as the face, neck, hands, or abdomen.\u003c\/li\u003e\n\u003cli\u003eEven the thighs and buttocks can be treated!\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor particularly dry or oxidatively damaged skin, Nucleofill 20 is perfectly suited, as it provides the skin of any condition with deep-acting moisture as well as extensive protection against free radicals. It also has an antioxidant effect based on polymerised polynucleotides.  Nucleofill 20 also stimulates cell formation by injecting it into the dermis for one to several sessions.\u003c\/p\u003e\n\u003cp\u003eIngredients: Aqua, Sodium DNA, Sodium Chloride\u003c\/p\u003e\n\u003cp\u003eCompatible with a mesotherapy protocol, not intended for volume enhancement\u003c\/p\u003e\n\u003cp\u003eNo needles included.\u003c\/p\u003e","brand":"Nucleofill","offers":[{"title":"Default Title","offer_id":57717432516956,"sku":"LPBST240","price":58.5,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1018\/4923\/5804\/files\/NUCLEOFILL_20_3.jpg?v=1779540934"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1018\/4923\/5804\/collections\/NUCLEOFILL_20_3.jpg?v=1780050093","url":"https:\/\/longevapharma.com\/collections\/nucleofill.oembed","provider":"Longeva Pharma","version":"1.0","type":"link"}